A U.S. Provision Patent Application has been filed for this technology
Nanofibrillated cellulose material embedded with photosensitive molecules for use as an antimicrobial and antiviral additive
Microbial contamination costs billions in damage, resulting in health risks, infections and biofouling. To prevent and kill microbes, antibiotics are added into materials that are susceptible to microbial growth or that come into human contact. Antibiotics, however, can be expensive, toxic to human health or become ineffective due to microbial resistance. Photodynamic inactivation (PDI) has emerged as an alternative treatment for microbial contamination and infections. PDI inactivates microbes without using antibiotics, allowing for non-target specificity without the potential for microbial resistance.
Researchers at NC State have developed a nanofibrillated photosensitive cellulose additive that uses PDI to prevent bacterial growth and kill microbes in medical devices, clothing, wallpaper, linens, food wrappers and other items. In the presence of visible light, the photosensitive molecules generate singlet oxygen molecules and free radicals that kill microbial cells. The additive is easy to apply as it can be sprayed, brushed or 3D-printed and is effective against bacteria, viruses and fungi. In addition, the technology is renewable, compostable, biocompatible and biodegradable, making it an environmentally friendly and cost-effective antimicrobial additive for consumer and commercial goods.
- Cellulose-based material that is biocompatible and biodegradable
- Nanofibrillated for strength, durability, stability and resistance to changes in heat
- Generates singlet oxygen molecules and free radicals using a non-toxic photosensitizer
- Effective against a variety of pathogens, including bacteria, viruses and fungi
- Synthesis, Characterization, and Antimicrobial Efficacy of Photomicrobicidal Cellulose Paper
- Porphyrin-Cellulose Nanocrystals: A Photobactericidal Material that Exhibits Broad Spectrum Antimicrobial Activity
- Photobactericidal Porphyrin-Cellulose Nanocrystals: Synthesis, Characterization, and Antimicrobial Properties
About the Inventors
Dr. Reza Ghiladi is an Associate Professor in the Department of Chemistry at NC State. He received his Ph.D. in Chemistry from John Hopkins University. His research interests include examining the multiple roles of metal ions in biology and medicine, chemical synthesis as it pertains to photosensitizer development for antimicrobial photodynamic therapy, elucidating enzyme pathways pertinent to disease states and investigating the limits of protein design and engineering.
Dr. Dimitris Argyropoulos is the Finland Distinguished Professor in the Department of Forest Biomaterials at NC State. He received his Ph.D. in Organic Chemistry from McGill University in Canada. His research interests include developing processes, chemicals and materials to use renewable carbon present in trees, biomimetic and organometallic catalysis in oxidation of aromatic substrates and the creation of novel, smart, stimuli-responsive nano-materials based on cellulose nano crystals.
Dr. Frank Scholle is an Associate Professor in the Department of Biological Sciences at NC State. He received his Ph.D. in Microbiology and Immunology from the University of North Carolina at Chapel Hill. His research interests include development of broad-spectrum anti-infective materials, host-virus interaction, the innate immune system and the development of novel point of care diagnostics for viral infections.