North Carolina State University is seeking a partner to commercialize a novel thermally-actuated biliary stent.
Benign biliary strictures (BBS) are non-cancerous obstructions of the biliary duct, usually associated with post-surgical injuries or chronic inflammatory disorders. This life-threatening condition can lead to liver damage, cardiovascular instability, kidney failure and septic shock. Stenting of the obstructed bile duct using Endoscopic Retrograde Cholangiopancreatography (ERCP) is the surgical standard of care. While endoscopic stenting is highly effective in achieving bile duct patency, this procedure carries its own surgical risks: complications include pancreatitis, hemorrhage, and cholangitis. The plastic and metallic stents commonly used for ERCP-based treatment of BBS require endoscopic procedures for removal.
Researchers at North Carolina State University have developed a novel thermally-actuated metallic biliary stent that can remain in place long enough to achieve adequate remodeling and recanalization of the bile duct, and yet be easily removed via inductive heating to limit surgical complications. Preliminary tests using a shape memory alloy prototype confirm that large reductions in stent diameter (in excess of 50%) can be achieved via this approach.
Further potential applications of this technology include venous malformations which currently require multiple interventional radiographic procedures to achieve vascular occlusion.
- No surgery required for removal
- Removal tailored to individual patient’s needs/LI>
- Biocompatible construction
- Further applications
About the Inventors
Dr. Gregory Buckner’s research is interesting to students because it focuses on the development of technologies that address human health needs, because it balances mechanical and electrical systems design, and because of its “hands-on” nature. His students are engaged in research and development using theoretical, computational and experimental tools with a focus on technology transfer and commercialization.
Dr. Kyles Mathews' research foducses on Investigational and minimally invasive treatment modalities (surgical techniques, drug delivery methods and biomedical implants); evaluation of the influence of muscle transection on swallowing dysfunction and aspiration in dogs following a lateral surgical approach to the larynx; and evaluation of swallowing function in dogs undergoing surgery for the treatment of laryngeal paralysis, hyperparathyroidism or thyroid neoplasi..